Detalhe da pesquisa
1.
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
Nature
; 576(7786): 315-320, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31776516
2.
Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance.
PLoS Pathog
; 18(2): e1010278, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35130315
3.
Integrative Genetic Manipulation of Plasmodium cynomolgi Reveals Multidrug Resistance-1 Y976F Associated With Increased In Vitro Susceptibility to Mefloquine.
J Infect Dis
; 227(10): 1121-1126, 2023 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36478252
4.
Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor.
Antimicrob Agents Chemother
; 64(4)2020 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32041711
5.
Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology.
PLoS Pathog
; 12(11): e1005976, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27832198
6.
Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.
Proc Natl Acad Sci U S A
; 112(37): 11672-7, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26261345
7.
Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter.
Mol Microbiol
; 97(2): 381-95, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25898991
8.
Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology.
mBio
; 15(1): e0183223, 2024 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38059639
9.
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.
bioRxiv
; 2023 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37398288
10.
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.
Sci Adv
; 9(45): eadi2364, 2023 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37939186
11.
Causal chemoprophylactic activity of cabamiquine against Plasmodium falciparum in a controlled human malaria infection: a randomised, double-blind, placebo-controlled study in the Netherlands.
Lancet Infect Dis
; 23(10): 1164-1174, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37414066
12.
Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study and volunteer infection study.
Lancet Infect Dis
; 21(12): 1713-1724, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34715032
13.
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.
Elife
; 102021 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34279219
14.
Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness.
mBio
; 10(2)2019 04 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31040246
15.
Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.
ACS Infect Dis
; 5(1): 90-101, 2019 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30375858
16.
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine.
Nat Commun
; 9(1): 3314, 2018 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30115924
17.
Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter.
Sci Rep
; 8(1): 13578, 2018 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30206341
18.
A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine.
mBio
; 8(3)2017 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28487425
19.
Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.
Nat Commun
; 7: 11553, 2016 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27189525
20.
Plasmodium falciparum resistance to piperaquine driven by PfCRT.
Lancet Infect Dis
; 19(11): 1168-1169, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31657776